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Ko, Mei-Chuan
One or more keywords matched the following items that are connected to Ko, Mei-Chuan
Item TypeName
Concept beta-Endorphin
Concept Humans
Concept Receptors, Bombesin
Concept Down-Regulation
Concept Hot Temperature
Concept Pilot Projects
Concept Primates
Concept Injections, Intradermal
Concept Escherichia coli
Concept 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
Concept Sweetening Agents
Concept Drug Partial Agonism
Concept Pain Measurement
Concept Macaca mulatta
Concept Radioligand Assay
Concept Alfentanil
Concept Nicotinic Agonists
Concept Substance P
Concept Cannabinoids
Concept Inflammation
Concept Heating
Concept Cricetinae
Concept Ketamine
Concept Blood Glucose
Concept Acetylcholine
Concept Anesthesia, Local
Concept Interleukin-17
Concept Morphine Derivatives
Concept Receptors, Opioid
Concept Dermatology
Concept Diazepam
Concept Cell Membrane
Concept Crystallography, X-Ray
Concept Pain Threshold
Concept Sex Factors
Concept Hyperalgesia
Concept Analysis of Variance
Concept Diltiazem
Concept Antibody Formation
Concept Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Concept Enzyme Stability
Concept Reaction Time
Concept Interleukin-1beta
Concept Methylphenidate
Concept Nerve Growth Factors
Concept Toluene 2,4-Diisocyanate
Concept Bombesin
Concept Clostridium perfringens
Concept Diuresis
Concept Swimming
Concept Alzheimer Disease
Concept Spiro Compounds
Concept Binding Sites
Concept Macaca
Concept Phenalenes
Concept Dogs
Concept Animals
Concept Binding, Competitive
Concept Computer Simulation
Concept Histamine
Concept Interleukin-23
Concept Neurodegenerative Diseases
Concept Ligands
Concept Nephrectomy
Concept Molecular Dynamics Simulation
Concept Morphinans
Concept Reinforcement Schedule
Concept Butorphanol
Concept Receptors, Atrial Natriuretic Factor
Concept Cycloheptanes
Concept Mice, Knockout
Concept Buprenorphine
Concept Antibodies
Concept Receptors, Cannabinoid
Concept Natriuretic Peptide, Brain
Concept Grooming
Concept Benzomorphans
Concept Calcium
Concept Conditioning, Operant
Concept Dermatitis, Allergic Contact
Concept STAT3 Transcription Factor
Concept TRPV Cation Channels
Concept CHO Cells
Concept Blotting, Western
Concept Analgesics, Opioid
Concept Injections, Spinal
Concept Cinnamates
Concept Opioid Peptides
Concept Bradykinin
Concept Lipopolysaccharides
Concept Injections, Subcutaneous
Concept Cricetulus
Concept Anti-Inflammatory Agents, Non-Steroidal
Concept Hydrocortisone
Concept Dynorphins
Concept Neurotensin
Concept Drug Interactions
Concept Anticonvulsants
Concept Integrin beta3
Concept Restraint, Physical
Concept Area Under Curve
Concept Spectrometry, Mass, Electrospray Ionization
Concept Mice
Concept Inflammation Mediators
Concept Tritium
Concept tau Proteins
Concept Excitatory Amino Acid Antagonists
Concept Oxycodone
Concept Muscle Relaxation
Concept Immunoenzyme Techniques
Concept Drug Evaluation, Preclinical
Concept Thalamus
Concept Brain Chemistry
Concept Pyrroles
Concept Hypersensitivity
Concept Molecular Structure
Concept Mice, Inbred ICR
Concept Food Preferences
Concept Naproxen
Concept Nerve Fibers, Unmyelinated
Concept Cerebral Cortex
Concept Seizures
Concept Diabetes Mellitus, Type 2
Concept Mice, Inbred C57BL
Concept Haloperidol
Concept Anti-Inflammatory Agents
Concept Receptors, Opioid, mu
Concept Cells, Cultured
Concept Receptors, Nicotinic
Concept Microsomes, Liver
Concept Fentanyl
Concept Benzofurans
Concept Injections, Intraperitoneal
Concept Dopamine Uptake Inhibitors
Concept Guanosine 5'-O-(3-Thiotriphosphate)
Concept Drug Synergism
Concept Isotope Labeling
Concept Signal Transduction
Concept Heart Rate
Concept Glomerular Filtration Rate
Concept Receptors, Neurotensin
Concept RNA, Messenger
Concept Naltrexone
Concept Cytokines
Concept Enzyme-Linked Immunosorbent Assay
Concept Protein Binding
Concept Receptors, AMPA
Concept Disease Models, Animal
Concept Receptors, Opioid, kappa
Concept Injections, Intramuscular
Concept Calcium Channels, N-Type
Concept Calcium Channel Blockers
Concept Narcotics
Concept Temperature
Concept Muscle Contraction
Concept Motor Activity
Concept Keratinocytes
Concept Enkephalin, D-Penicillamine (2,5)-
Concept Data Interpretation, Statistical
Concept Blood Pressure
Concept Morphine
Concept Pain
Concept Dermatitis, Atopic
Concept Stereoisomerism
Concept Neuralgia
Concept Macaca fascicularis
Concept Prolactin
Concept Injections, Intraventricular
Concept Drug Design
Concept Drug Tolerance
Concept Tetrahydroisoquinolines
Concept Integrin alpha5
Concept Receptor, Bradykinin B1
Concept Mutagenesis, Site-Directed
Concept Ileum
Concept Pyrazoles
Concept Cell Degranulation
Concept Quantum Theory
Concept Narcotic Antagonists
Concept Polyethylene Glycols
Concept Naloxone
Concept Sensitivity and Specificity
Concept Alcohol Drinking
Concept Cell Adhesion Molecules
Concept Amitriptyline
Concept Benzimidazoles
Concept Cyclopropanes
Concept Gastrin-Releasing Peptide
Concept Injections
Concept Heroin
Concept Indoles
Concept Toll-Like Receptors
Concept Pyrrolidonecarboxylic Acid
Concept Macrophages
Concept Antipruritics
Concept Chemokine CCL3
Concept GTP-Binding Proteins
Concept Cisterna Magna
Concept Nalbuphine
Concept Kallidin
Concept Spectrometry, Fluorescence
Concept Atmospheric Pressure
Concept Guinea Pigs
Concept Sulfur Radioisotopes
Concept Adrenocorticotropic Hormone
Concept Hypothalamo-Hypophyseal System
Concept Rats
Concept Autoradiography
Concept Benzeneacetamides
Concept In Situ Hybridization
Concept Models, Molecular
Concept Benzamides
Concept Integrins
Concept Analgesics, Non-Narcotic
Concept Cell Membrane Permeability
Concept Butyrylcholinesterase
Concept Rhodococcus
Concept Rats, Wistar
Concept Cell Line
Concept Analgesics
Concept Posture
Concept Hydrolysis
Concept Clonidine
Concept Eating
Concept Rats, Sprague-Dawley
Concept Vas Deferens
Concept Carboxylic Ester Hydrolases
Concept Central Nervous System Agents
Concept Protein Conformation
Concept Capsaicin
Concept Trypsin
Concept Tyrphostins
Concept Gas Gangrene
Concept Neurokinin B
Concept Chemokines
Concept Hypothermia
Concept Benzazepines
Concept Enkephalins
Concept Receptors, Opioid, delta
Concept Interferon Type I
Concept Injections, Intravenous
Concept Neurotransmitter Agents
Concept Antidepressive Agents
Concept Cell Line, Tumor
Concept Brain-Derived Neurotrophic Factor
Concept Freezing Reaction, Cataleptic
Concept Electrocardiography
Concept Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
Concept Pituitary-Adrenal System
Concept Atrial Natriuretic Factor
Concept Estrogen Receptor alpha
Concept Phosphorylation
Academic Article Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.
Academic Article Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/µ-opioid receptor ligands in mouse models of neuropathic and inflammatory pain.
Academic Article Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice.
Academic Article The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeys.
Academic Article Cocaine esterase: interactions with cocaine and immune responses in mice.
Academic Article Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.
Academic Article The role of central gastrin-releasing peptide and neuromedin B receptors in the modulation of scratching behavior in rats.
Academic Article The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination.
Academic Article Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys.
Academic Article Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates.
Academic Article Roles of µ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates.
Academic Article Antinociceptive effects of nociceptin/orphanin FQ administered intrathecally in monkeys.
Academic Article Behavioral effects of a synthetic agonist selective for nociceptin/orphanin FQ peptide receptors in monkeys.
Academic Article Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats.
Academic Article The therapeutic potential of nociceptin/orphanin FQ receptor agonists as analgesics without abuse liability.
Academic Article Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.
Academic Article Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.
Academic Article Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats.
Academic Article Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies.
Academic Article Effects of butorphanol on morphine-induced itch and analgesia in primates.
Academic Article Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Academic Article Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats.
Academic Article Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys.
Academic Article The spinal antinociceptive effects of endomorphins in rats: behavioral and G protein functional studies.
Academic Article Most efficient cocaine hydrolase designed by virtual screening of transition states.
Academic Article Electrospray sample deposition for matrix-assisted laser desorption/ionization (MALDI) and atmospheric pressure MALDI mass spectrometry with attomole detection limits.
Academic Article Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity.
Academic Article Effects of cocaine esterase following its repeated administration with cocaine in mice.
Academic Article PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity.
Academic Article Structural analysis of thermostabilizing mutations of cocaine esterase.
Academic Article Pharmacokinetic evidence for the long-lasting effect of nor-binaltorphimine, a potent kappa opioid receptor antagonist, in mice.
Academic Article Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain.
Academic Article [Dmt1]N/OFQ(1-13)-NH2: a potent nociceptin/orphanin FQ and opioid receptor universal agonist.
Academic Article Seizure activity involved in the up-regulation of BDNF mRNA expression by activation of central mu opioid receptors.
Academic Article Effects of intrathecally administered nociceptin/orphanin FQ in monkeys: behavioral and mass spectrometric studies.
Academic Article Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through delta- and micro-opioid receptors independent of antidepressant-like effects.
Academic Article Differential in vivo potencies of naltrexone and 6beta-naltrexol in the monkey.
Academic Article How best to fight that nasty itch - from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches.
Academic Article Antinociceptive, hypothermic, hypotensive, and reinforcing effects of a novel neurotensin receptor agonist, NT69L, in rhesus monkeys.
Academic Article Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist.
Academic Article The role of central mu opioid receptors in opioid-induced itch in primates.
Academic Article Characterization of scratching responses in rats following centrally administered morphine or bombesin.
Academic Article Ultra-long antagonism of kappa opioid agonist-induced diuresis by intracisternal nor-binaltorphimine in monkeys.
Academic Article Effect of opioid receptor antagonists on hypothalamic-pituitary-adrenal activity in rhesus monkeys.
Academic Article Studies of micro-, kappa-, and delta-opioid receptor density and G protein activation in the cortex and thalamus of monkeys.
Academic Article Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys.
Academic Article Relative reinforcing effects of three opioids with different durations of action.
Academic Article Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors.
Academic Article Gangrenous Clostridium perfringens infection and subsequent wound management in a rhesus macaque (Macaca mulatta).
Academic Article Comparison of the opioid receptor antagonist properties of naltrexone and 6 beta-naltrexol in morphine-naïve and morphine-dependent mice.
Academic Article Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists.
Academic Article Effects of the NOP agonist SCH221510 on producing and attenuating reinforcing effects as measured by drug self-administration in rats.
Academic Article Neuraxial opioid-induced itch and its pharmacological antagonism.
Academic Article Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates.
Academic Article TC-2559, an a4ß2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1ß through STAT3 inhibition in cultured murine macrophages.
Academic Article Central N/OFQ-NOP Receptor System in Pain Modulation.
Academic Article Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice.
Academic Article Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys.
Academic Article Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates.
Academic Article GR89,696: a potent kappa-opioid agonist with subtype selectivity in rhesus monkeys.
Academic Article Local inhibitory effects of dynorphin A-(1-17) on capsaicin-induced thermal allodynia in rhesus monkeys.
Academic Article Diltiazem enhances the analgesic but not the respiratory depressant effects of morphine in rhesus monkeys.
Academic Article An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception.
Academic Article Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats.
Academic Article Activation of peripheral kappa opioid receptors inhibits capsaicin-induced thermal nociception in rhesus monkeys.
Academic Article Intracisternal nor-binaltorphimine distinguishes central and peripheral kappa-opioid antinociception in rhesus monkeys.
Academic Article The effects of the phyllolitorin analogue [desTrp(3), Leu(8)]phyllolitorin on scratching induced by bombesin and related peptides in rats.
Academic Article Comparison of Antinociceptive Effects Induced by Kappa Opioid Agonists in Male and Female Mice.
Academic Article Differentiation of kappa opioid agonist-induced antinociception by naltrexone apparent pA2 analysis in rhesus monkeys.
Academic Article kappa-Opioid receptor binding populations in rhesus monkey brain: relationship to an assay of thermal antinociception.
Academic Article The role of peripheral mu opioid receptors in the modulation of capsaicin-induced thermal nociception in rhesus monkeys.
Academic Article A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates.
Academic Article Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys.
Academic Article Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt1]N/OFQ(1-13).
Academic Article Differential mRNA expression of neuroinflammatory modulators in the spinal cord and thalamus of type 2 diabetic monkeys.
Academic Article A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates.
Academic Article Effects of NOP-Related Ligands in Nonhuman Primates.
Academic Article Neuromedin B Induces Acute Itch in Mice via the Activation of Peripheral Sensory Neurons.
Academic Article BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates.
Academic Article Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys.
Academic Article Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates.
Academic Article Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch.
Academic Article GRP receptor and AMPA receptor cooperatively regulate itch-responsive neurons in the spinal dorsal horn.
Academic Article Therapeutic potentials of NOP and MOP receptor coactivation for the treatment of pain and opioid abuse.
Academic Article Antinociceptive, reinforcing, and pruritic effects of the G-protein signalling-biased mu opioid receptor agonist PZM21 in non-human primates.
Academic Article STING controls nociception via type I interferon signalling in sensory neurons.
Academic Article Pleiotropic Effects of Kappa Opioid Receptor-Related Ligands in Non-human Primates.
Academic Article Synthesis of Enantiopure PZM21, A Novel Biased Agonist of the Mu-Opioid Receptor.
Academic Article Nociceptin/Orphanin FQ Peptide Receptor-Related Ligands as Novel Analgesics.
Academic Article Translational value of non-human primates in opioid research.
Academic Article Usefulness of the measurement of neurite outgrowth of primary sensory neurons to study cancer-related painful complications.
Academic Article Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.
Academic Article Functional Profile of Systemic and Intrathecal Cebranopadol in Nonhuman Primates.
Academic Article Morphine acts on spinal dynorphin neurons to cause itch through disinhibition.
Academic Article Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates.
Academic Article Functional consequences of short-term exposure to opioids versus cannabinoids in nonhuman primates.
Academic Article Characterization of Early Alzheimer's Disease-Like Pathological Alterations in Non-Human Primates with Aging: A Pilot Study.
Academic Article Potential therapeutic targets for the treatment of opioid abuse and pain.
Academic Article IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.
Academic Article Chemogenetic activation of central gastrin-releasing peptide-expressing neurons elicits itch-related scratching behavior in male and female mice.
Academic Article [Therapeutic potentials of safe opioid analgesics targeting nociceptin/orphanin FQ peptide receptor].
Academic Article Enhanced antidepressant-like effects of a delta opioid receptor agonist, SNC80, in rats under inflammatory pain.
Academic Article Nociceptin Receptor-Related Agonists as Safe and Non-addictive Analgesics.
Academic Article PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior.
Search Criteria
  • Enkephalin
  • Ala
  • 2
  • MePhe
  • 4
  • Gly
  • 5